Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation

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Benjamin J. Lichtbroun
Brian Shinder
Tina Gowda Sara
Arnav Srivastava
Biren Saraiya
Tina M. Mayer
Ryan Cristelli
Evita Sadimin
Robert E. Weiss
Eric A. Singer


chromophobe renal cell carcinoma, immune checkpoint inhibitors, kidney cancer, sarcomatoid


Chromophobe renal cell carcinoma (chRCC) is one of the less common types of kidney cancer and generally portends a more favorable prognosis. RCC with sarcomatoid differentiation has a more aggressive clinical course with poor outcomes. Four cases of chRCC with varying degrees of sarcomatoid differentiation were retrospectively reviewed at our institution, and clinicopathologic data as well as clinical courses were reported. Patients with higher degrees of sarcomatoid differentiation and larger tumors at presentation generally had and worse overall survival. chRCC with sarcomatoid differentiation portends a poor prognosis with limited data on systemic treatment options for metastatic disease.

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